Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated

VRTX
Vertex Pharmaceuticals IncorporatedUS flagNASDAQ Global Select
498.43
USD
-23.82
- -
126.50BMarket Cap
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
5.39
2.47
4.28
6.96
10
11.98
16.21
23.88
29.39
34.87
38.3
42.73
46.94
47.9
Basic EPS, GAAP
-1.98
-3.14
-2.31
-0.46
1.06
8.25
4.58
10.44
9.09
12.97
14.05
-2.08
15.46
17.01
Free Cash Flow per Basic Share
-0.5
-2.65
-1.7
0.73
2.35
4.62
5.82
11.52
9.35
15.33
12.72
-3.79
12.49
14.55
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-17.63
-19.99
-21.79
-21.95
-20.56
-11.75
-7.21
3.31
12.43
25.48
39.37
37.26
53.04
57.21
Tangible Book Value per Share
5.89
4.37
3.14
4.1
7.89
17.24
18.24
28.03
33.75
47.72
60.74
56.21
67.08
70
Basic Weighted Avg Shares
225
235
241
245
249
254
257
260
258
256
258
258
256
255
Sales/Revenue/Turnover
1,212
580
1,032
1,702
2,489
3,048
4,163
6,206
7,574
8,931
9,869
11,020
12,001
12,218
Operating Margin (%)
-12.92
-110.52
-45.01
0.66
15.78
21.79
28.87
46.24
36.69
47.59
38.31
-2.12
37.95
38.16
Depreciation Expense
48
63
62
61
61
72
107
110
126
148
181
207
210
217
Net Income, GAAP
-445
-739
-556
-112
263
2,097
1,177
2,712
2,342
3,322
3,620
-536
3,953
4,338
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
15.64
13
14.22
21.51
17.36
315.53
14.86
16.02
Profit Margin (%)
-36.72
-127.25
-53.89
-6.58
10.59
68.8
28.27
43.7
30.92
37.2
36.68
-4.86
32.94
35.51
Working Capital
1,191
1,178
901
1,039
1,842
2,723
3,488
6,256
7,419
10,493
10,597
6,032
7,340
7,850
LT Debt
490
793
739
521
584
582
623
890
887
810
725
1,657
1,953
1,986
Total Equity
1,356
1,096
1,094
1,338
2,042
4,435
6,085
8,687
10,100
13,913
17,580
16,410
18,666
19,362
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
17.07
30.18
22.7
25.45
18.69
2.73
19.83
19.83
Return on Capital (%)
- -
- -
- -
- -
- -
- -
-68.33
913.96
80.31
58.04
39.79
-5.39
29.42
30.52
Return on Common Equity (%)
- -
- -
- -
- -
- -
- -
- -
- -
115.24
68.29
43.43
-5.42
34.12
34.92

Capital Structure

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
ST Debt
- -
77
- -
LT Borrowings
- -
- -
- -
LT Finance Leases
1,835
1,953
1,986
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
254
254
254
Market Capitalization
100,524
115,958
113,901

Working Capital

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
Total Current Assets
10,570
11,201
11,730
Cash, Cash Equivalents & STI
6,287
6,608
7,247
Accounts Receivable, Net
1,946
2,053
1,996
Inventories
1,627
1,687
1,767
Total Current Liabilities
4,475
3,861
3,881
Payables & Accruals
4,034
3,484
3,474
ST Debt
- -
77
- -
Deferred Revenue
- -
172
- -

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
35.96%
17.49%
13.75%
Free Cash Flow
-21.88%
-105.89%
-426.56%
Net Income, GAAP
-54.83%
-183.14%
-838.09%
Sales/Revenue/Turnover
29.03%
14.21%
8.9%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
2,691
2,646
2,772
2,912
11,020
2025
2,770
2,965
3,076
3,190
12,001
2026
2,987
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
4.26
-13.92
4.05
3.55
-2.08
2025
2.52
4.02
4.24
4.69
15.46
2026
4.06
- -
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

APIChatGPT
CEO
Reshma Kewalramani
Full Time Employees
6,100
Sector
Healthcare
Industry
Biotechnology
Address
50 Northern Avenue Boston MA United States of America 02210
IPO Date
Jul 24, 1991
Website
vrtx.com
Business
Vertex Pharmaceuticals Incorporated (VRTX), headquartered in Boston, Massachusetts and founded in 1989, develops, manufactures and commercializes transformative medicines for serious diseases, with a primary focus on cystic fibrosis, sickle cell disease, beta thalassemia and emerging areas including pain, kidney disease and type 1 diabetes; its portfolio features the CFTR modulators TRIKAFTA/KAFTRIO, ALYFTREK, SYMDEKO/SYMKEVI, ORKAMBI and KALYDECO, the CRISPR/Cas9 gene-edited therapy CASGEVY (co-developed with CRISPR Therapeutics), the non-opioid NaV1.7 pain treatment JOURNAVX/suzetrigine, and investigational assets such as povetacicept (for IgA nephropathy and other autoimmune kidney diseases), inaxaplin (for APOL1-mediated kidney disease), VX-407 (for autosomal dominant polycystic kidney disease), VX-522 (CFTR mRNA therapy with Moderna), VX-880/VX-264 (stem cell therapies for type 1 diabetes) and VX-993 (next-generation pain candidate); the company operates research facilities in San Diego, California and Milton Park, Oxfordshire, UK, with commercial presence across North America, Europe, Australia, Asia and the Middle East. In recent developments, Vertex completed its $4.9 billion acquisition of Alpine Immune Sciences in 2024 to secure povetacicept, entered an exclusive collaboration with Ono Pharmaceutical in June 2025 for povetacicept commercialization in Japan and South Korea (building on a prior deal with Zai Lab), launched ALYFTREK in the US and began European reimbursement efforts in England, Germany and Denmark, advanced CASGEVY and JOURNAVX launches with expanding US coverage including major PBMs and hospital networks, completed Phase 3 enrollment for povetacicept in IgA nephropathy (targeting accelerated US approval in H1 2026), initiated VX-407 Phase 2 proof-of-concept for ADPKD, progressed VX-522 Phase 1/2 data readout in H1 2025 and discontinued standalone development of an experimental pain drug following mid-stage failure while prioritizing suzertrigine/JOURNAVX expansion. Vertex reported Q3 2025 total revenues of $3.08 billion (up 11% year-over-year), driven by CF franchise growth, early new product contributions and favorable US pricing, with full-year 2025 guidance refined to $11.9-12.0 billion.

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